AB3217-A, a novel anti-mite substance produced by a strain of Streptomyces platensis.
نویسندگان
چکیده
AB3217-A, a novel anti-mite substance, was isolated from the fermentation broth of a streptomycete strain. The strain was isolated from a soil collected at Kita-azumi, Nagano Prefecture, Japan, and identified as Streptomyces platensis AB3217. AB3217-A was purified by Amberlite IR120B, Diaion HP-20 and CM-Sephadex C-25 column chromatographies. The molecular formula was determined as C17H23NO7 by elemental analysis, MS and 13C NMR spectroscopy. The structure of AB3217-A was determined to be (1R,3S,4S,7R,8R,11R,12S,13R)-4,12,13-trihydroxy-8-(4-methoxy phenyl)-6-aza-2,9,14-trioxatricyclo-[9.2.1.0(3,7)]tetradecane by spectroscopic analysis and X-ray crystallographic analysis. The molecule of AB3217-A has unique structure that deacetylanisomycin and beta-D-xylofuranose linked through glycosidic bond and ether bond resulting in the formation of nine-membered ring. AB3217-A showed marked activity against the two spotted spider mite, Tetranychus urticae.
منابع مشابه
Isolation and structures of two novel anti-mite substances, AB3217-B and C.
We previously reported1} the isolation and structure determination of a novel anti-mite substance, AB3217-A (1), one of the components of an anti-mite substance complex produced by Streptomycesplatensis AB321 7. Following improvements in the isolation method of AB3217-Afrom cultured broth, we found that the strain produced two new minor components, AB3217-B (2) and C (3), which were structurall...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 45 4 شماره
صفحات -
تاریخ انتشار 1992